Longevity Office operates as Germany's first AI-supported longevity clinic, physically located within the German Clinic for Diagnostics (DKD) in Wiesbaden. The clinic is led by Dr. Mario Domeyer and Dr. Paul Weißenfels, experienced internists specializing in preventive medicine and systems medicine.
The clinic applies a preventive and diagnostic-first approach, replacing isolated annual check-ups with a structured 12-month medical system. This system includes four major medical review stages — an onboarding phase followed by three focused Longevity Sprints — each informed by updated diagnostics and continuous data analysis.
All consultations are conducted via secure video calls. Diagnostic tests can be completed at local laboratories across Germany, allowing patients to participate from anywhere in the country without traveling to Wiesbaden. The clinic operates without sponsors or commercial partnerships, limiting its scope strictly to peer-reviewed, evidence-based medical protocols.
➡️ For a broader comparison of physician-led preventive models across the country, you can explore our overview of the best longevity clinics in Germany.
At a GlanceLongevity Office
- Official Name: Longevity Office
- Address: German Clinic for Diagnostics (DKD), Wiesbaden, Germany
- Medical Director: Dr. Mario Domeyer & Dr. Paul Weißenfels
- Clinic Type: Physician-led longevity & preventive medicine clinic
- Core Framework: The 5 Attackers: Cardiovascular, Cancer, Metabolic, Performance, Biological Aging
- Medical Approach: Systems medicine, evidence-based, data-driven
- Care Model: Digital-first; remote video consultations
- Diagnostic Depth: Hundreds of biomarkers, epigenetic testing, imaging, wearables, CGM
- Signature Program: 12-month structured system with four iterations (Onboarding + 3 Longevity Sprints)
- AI Technology: Personalized Longevity-GPT trained on patient's own medical data
- Signature Method: 12-month structured system with four iterations
- Privacy Level: Medical-grade confidentiality
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Use the Quick Links below to navigate directly to the sections most relevant to your visit.
- Germany's first AI-supported longevity practice: Medical expertise is combined with modern technology. Each patient receives a personalized, doctor-curated Longevity AI (Health-GPT) trained exclusively on their individual medical data.
- Co-founded by: Dr. Mario Domeyer and Dr. Paul Weißenfels lead all clinical decisions, ensuring physician authority at every stage of care.
- Structured 12-month medical system: The program replaces one-off annual check-ups with a continuous cycle — Onboarding followed by three iterative Longevity Sprints — reviewed and adjusted every 90 days.
- Targeting The 5 Attackers: Clinical focus is directed at the primary drivers of age-related death: cardiovascular disease, cancer, metabolic dysfunction, physical and cognitive performance decline, and biological aging.
- Location-independent digital care: The full program is designed to work remotely through video consultations and secure digital data uploads, with no requirement to travel to Wiesbaden.
- Deep systems medicine approach: The 3-Hever-Principle is applied to every health risk — minimize harm, control growth signals, and strengthen protective mechanisms.
- Data-driven transparency: Hundreds of laboratory parameters, wearable sensor data, and imaging are combined to build a comprehensive, individualized Longevity Roadmap
Clinical Purpose
Longevity Office’s clinical purpose is to support the systematic extension of healthspan by identifying and managing disease risks at a pre-clinical stage. The clinic focuses on understanding how multiple biological systems interact over time, rather than responding to symptoms once disease is established.
Medical decisions are informed by comprehensive diagnostics, repeated data review, and physician oversight. The clinic’s role is to provide structure, interpretation, and continuity—without urgency framing, fear-based messaging, or outcome guarantees.
Sustained professional pressure often reshapes metabolic and cardiovascular risk patterns over time, explored further in stress after thirty-five.
Who This Clinic Is Designed For
Based on its operational model and patient profiles, Longevity Office is designed for:
- Executives and senior professionals
- Founders and entrepreneurs
- Engineers, pilots, and technical specialists
- Investors and decision-makers
- Individuals with family histories of chronic illness
- Proactive adults seeking evidence-based prevention rather than reactive care
The clinic is not positioned for acute treatment or short-term wellness goals, but for individuals seeking clarity, oversight, and long-term medical planning.
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Focus Area
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What This Means in Practice
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Medical Discipline
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Preventive and systems-oriented medicine led by licensed physicians
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Core Biological System
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Cardiovascular risk, metabolic function, cancer risk, performance decline, biological aging
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Environment & Design
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Clinical, calm, privacy-focused setting with a digital-first care model
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Program Structure
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Structured 12-month medical system with continuous monitoring
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Lifestyle as Medicine
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Sleep, activity, glucose trends, and stress reviewed as medical data inputs
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Privacy
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Medical-grade data protection and discreet, physician-led information handling
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Long-Term Strategy
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Longitudinal monitoring and health planning rather than episodic care
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Longevity Office operates on a systems medicine philosophy under the direction of founders Dr. Mario Domeyer and Dr. Paul Weißenfels. Rather than addressing isolated symptoms or markers, the clinic evaluates how multiple biological systems interact over time and how early risk patterns develop before disease becomes clinically visible.
The practice's founding philosophy holds that 'health is shapeable' — but that shaping it requires a clear, structured path. The founders aim to translate medical evidence into safe, actionable protocols that treat aging as the root driver of disease, rather than simply managing symptoms after they appear.
Core System Focus - The 5 Attackers
Clinical attention is directed toward the primary five drivers of age-related disease and mortality:
- Cardiovascular risk
- Cancer risk
- Metabolic dysfunction
- Physical and cognitive performance decline
- Biological ageing processes
Each area is assessed through validated diagnostics and reviewed across multiple iterations during the year
Hormonal resilience and long-term health planning are explored in greater depth in our feature on women and longevity.
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🔍 Did You Know?
According to large epigenetic studies published in Nature Aging and BMC Medicine, biological age can differ significantly from chronological age. Researchers show that lifestyle factors such as glucose control, sleep, and smoking avoidance influence the pace of aging far more than genetics alone.
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The Longevity Office applies high-resolution diagnostics to move beyond standard screening thresholds. The goal is not diagnosis of disease, but risk stratification and monitoring. A systematic review in Diabetes Care found that Continuous Glucose Monitoring (CGM) helps identify hidden metabolic stress that often remains invisible in standard fasting blood tests.
Additional research in the International Journal of Behavioral Nutrition and Physical Activity shows that real-time glucose feedback supports long-term behavior awareness rather than short-term dieting.
Diagnostic Assessment Includes
- Comprehensive blood biomarker panels
- Genetic and epigenetic testing
- Imaging studies (MRI / CT where clinically appropriate)
- Continuous Glucose Monitoring (CGM)
- Integration of wearable data (e.g., Apple Watch, Oura Ring)
Data is collected from specialty laboratories and local diagnostic centers across Germany, allowing patients to participate without centralized testing visits.
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🔍 Did You Know?
Long-term population studies published in BMC Medicine suggest that genetics account for less than 10% of how people age. More than 90% of aging outcomes are shaped by lifestyle, environment, and metabolic health.
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Key Medical Strength 1 – Continuous Medical Structure
Longevity Office replaces episodic appointments with a structured 12-month medical system
consisting of five major stages. Each iteration incorporates new diagnostic data and updated
physician interpretation, allowing the medical team to assess whether risk markers are
stable, improving, or progressing — something not possible with a one-off check-up.
Key Medical Strength 2 – Health Support (Personalized AI Support)
Each patient receives a custom Health GPT, trained exclusively on their own medical data.
The AI does not provide medical decisions or advice. Its role is to
- Translate complex lab data into plain language
- Support patient understanding between appointments
- Help structure questions for physician consultations
This creates continuity between formal medical reviews without replacing physician
authority. The clinic's operating model is built on a Longevity Triangle: Physician (decision-
making) — Health GPT (data organization and explanation) — Patient (execution and
awareness).
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🔍 Did You Know?
Patients can interact with their Health GPT at any time — for
example, asking: 'How did my LDL change relative to my sleep habits?' — based on their own complete medical history. Additionally, patients can submit questions at any time via the platform, which are answered asynchronously by the medical team.
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Key Medical Strength 3 – Physician-Led Interpretation
Despite advanced data and AI support, clinical judgment remains central. All findings are
reviewed by Dr. Domeyer and Dr. Weißenfels, who contextualize results within each
patient's full medical and risk profile. The clinic provides a medical Longevity Roadmap —
transforming massive amounts of data into clear, individualized, actionable instructions.
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🔍 Did You Know?
The widely cited “Hallmarks of Aging” framework, published in the International Journal of Molecular Sciences, explains that aging is driven by interconnected biological processes such as inflammation, metabolic dysfunction, and cellular stress — not by a single cause.
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The following outcomes are drawn directly from documented clinical case material and patient testimony referenced in the research. They are presented for contextual understanding only, not as expected or guaranteed results.
Ricardo Abrantes — Veterinary Cardiologist
'As a physician myself, I am highly critical of medical programs that rely on trends or vague promises. Longevity Office impressed me with its structured thinking and depth of data analysis. The combination of specialist oversight and a personalized AI gave me continuous clarity about my cardiovascular risk and actionable steps to reduce it. It feels like having a second brain focused entirely on my health.'
Background: Veterinary Cardiologist
Focus: Cardiovascular risk monitoring and structured medical oversight
Holger Zapf — Technology & Engineering Professional
'The Longevity-GPT completely changed how I interact with my health data. Instead of receiving complex lab reports once a year, I can explore relationships between sleep, biomarkers, and performance at any time. The system allows me to approach my health analytically, from multiple perspectives, without feeling overwhelmed.'
Background: Technology & Engineering
Focus: Ongoing data interpretation and personalized AI support
S.P. — Executive, Preventive Health Client
'What I value most is the sense of security between doctor appointments. Whenever a lab value changes or I notice something in my wearable data, the AI helps me interpret it in plain language. This ongoing support removes anxiety and makes the whole process feel calm, controlled, and proactive.'
Background: Executive (anonymous)
Focus: Continuity of care and AI-assisted data interpretation between consultations
Dr. Andreas R. — Chemist, Metabolic Health Focus
'The program helped me understand my metabolic risks long before they would have appeared in a standard check-up. Through structured iterations and precise biomarkers, I was able to improve my weight, glucose regulation, and overall energy levels. The medical reasoning behind every recommendation was transparent and scientifically sound.'
Background: Chemist
Outcome: Resolved pre-diabetic state; lost approximately 25 kg through metabolic optimization
Anonymous Patient — Remote Digital Care User
'I never had to travel to Wiesbaden, yet the care felt more continuous than any in-person clinic I've used before. Blood tests at my local lab, video consultations, and constant AI support created a seamless experience. This is the first time medicine has felt like an ongoing system rather than a once-a-year event.'
Background: Remote patient (anonymous)
Focus: Location-independent care and digital-first program experience
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⚠️ Editorial Note
These outcomes reflect individual experiences reported within the clinic’s published materials. Results vary. Diagnostics indicate risk patterns, not certainty, and outcomes depend on multiple individual factors.
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Longevity Office structures its services around a 12-month medical system and longitudinal
oversight. Programs are designed to support continuous assessment, interpretation, and
monitoring — not short-term interventions.
Program Overview
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Program
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Duration
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Starting Price |
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Longevity Initial (First Consultation)
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Single Session
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On request — billed per GOÄ |
Detailed Longevity Lab (60+ parameters) |
As indicated
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On request |
12-Month Longevity Programme |
12 Months
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On consultation |
Personalised Health-GPT |
Ongoing
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Included in programme |
| Free Longevity Kompass Assessment |
8-10 minutes online |
Free |
Note: All pricing is billed per the German Medical Fee Schedule (GOÄ). A full cost overview is provided to each patient before starting. Private insurers may reimburse parts depending on tariff. Statutory (GKV) patients are self-payers. No fixed public prices are listed by the clinic.
1. 12-Month Longevity Program - 5 Stages
This is the clinic’s core medical offering.
Program Characteristics:
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Onboarding (45-minute call) Month 0: Full medical history, baseline diagnostics, personalized Health GPT setup, Longevity Roadmap created
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Iteration 1 - Month 3: Lab re-evaluation, wearable data review, roadmap updated
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Iteration 2 - Month 6: Mid-program reassessment, strategy adjusted based on trend data
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Iteration 3 - Month 9: Third data review, further optimization\
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Rückblick & Renewal - Month 12: Full-year review, outcomes assessed, optional program renewal
The program replaces isolated check-ups with a continuous medical system intended to support long-term health planning.
Longevity Hubs — Regional Diagnostic Network
Longevity Office operates 8 regional Longevity Hubs across Germany, functioning as local diagnostic partner centers. These hubs allow patients to complete blood tests, imaging, and other assessments at a location near them, without traveling to Wiesbaden.
• Frankfurt
• München
• Berlin
• Hamburg
• Düsseldorf
• Köln
• Stuttgart
• Leipzi
Free Longevity Kompass
The clinic offers a free ~8-minute Longevity Kompass assessment quiz with personalized PDF output. This is the recommended entry point for prospective patients before booking a consultation.
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🔍 Did You Know?
Research published in the Journal of Medical Internet Research shows that wearable devices are most valuable when used for trend tracking over time, not as diagnostic tools on their own.
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Longevity Office operates within a clinical and diagnostic setting, not a therapeutic or wellness environment. The clinic is physically based at the German Clinic for Diagnostics (DKD) in Wiesbaden and functions primarily through a digital-first medical workflow.
Clinical Facilities
- Specialized diagnostic infrastructure
- Imaging capabilities
- Multidisciplinary medical expertise across multiple specialties
This setting supports the clinic’s focus on high-resolution diagnostics rather than on-site treatment delivery.
Environment, Privacy & Digital Discipline
Longevity Office emphasizes:
- Medical-grade data protection
- Secure digital communication
- Minimal operational friction for patients
The digital-first model allows patients to engage with the clinic without repeated physical presence, while maintaining structured medical oversight.
Longevity Office does not publish fixed prices. All services are billed per the German Medical Fee Schedule (GOÄ). A full and transparent cost overview is provided to each patient before starting.
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Pricing Basis
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German Medical Fee Schedule (GOÄ) — bespoke quote per patient
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Entry Point
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Longevity Initial consultation — price provided on request
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Lab Analysis
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Detailed Longevity Lab (60+ parameters) — price provided on request
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Programme Pricing
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Confirmed after initial consultation
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Private Insurance
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Private insurers may reimburse parts, depending on individual tariff
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Statutory Insurance (GKV)
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GKV patients are self-payers; GKV does not cover this program.
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Length of Stay
There is no required on-site stay. All medical consultations are conducted via video, and diagnostic testing can be completed at local laboratories throughout Germany. Physical presence in Wiesbaden is not a prerequisite for participation.
While not required, patients who wish to visit the physical clinic at the German Clinic for Diagnostics (DKD) in Wiesbaden can do so. The nearest major airport is Frankfurt am Main (FRA), with a transfer time of approximately 40–60 minutes by train or car. International visitors sometimes integrate their consultations into a broader journey using our structured 10-day Germany itinerary as a reference.
Recommended Length of Stay
- No mandatory on-site stay
- Medical consultations are conducted remotely
- Diagnostic testing can be completed at local laboratories across German
- Physical presence in Wiesbaden is optional and context-dependent
The clinic’s model prioritizes continuity and longitudinal assessment rather than intensive short-term visits.
How to Reach Wiesbaden?
For individuals who choose or need to visit Wiesbaden:
- Nearest major airport: Frankfurt am Main Airport
- Approximate transfer time: ~30 minutes to Wiesbaden
- Transport options: Train or car
Travel planning is outside the clinic’s core medical services and is managed independently by patients.
🔗 Find best flights to Wiesbaden
🔗 Find car rentals in Wiesbaden
Links provided for travel planning convenience only.
Accommodation & Stay Planning
Longevity Office does not operate its own accommodation. Patients who choose to visit Wiesbaden typically stay in nearby hotels or private accommodation, selected independently based on personal preference, schedule, and comfort requirements. For convenience, the Stay22 map below allows visitors to explore accommodation options around the clinic’s location, compare areas, and plan a stay that fits their itinerary.
If your schedule includes other major cities, you may also review curated suggestions in our guide to things to do in Berlin.
🔗 Explore nearby hotels & apartments
What to Bring
- Relevant prior medical records (if available)
- Access to wearable data, if already in use
Longevity Office is positioned within Germany’s preventive and systems medicine landscape and operates from the German Clinic for Diagnostics (DKD) in Wiesbaden. Its work is referenced through:
- The clinic’s own Evidence Hub and published clinical protocols
- Physician-authored explanations of its medical framework
- Patient testimonials from medical professionals, engineers, executives, and scientists
Expert voices associated with the clinic, including its founding physicians, emphasize a shift away from reactive care toward structured, data-driven prevention. This positioning is professional rather than media-driven, with no reliance on lifestyle press or wellness endorsements.
What is the Longevity Office in Germany?
Longevity Office is a physician-led longevity and preventive medicine clinic based in Wiesbaden, Germany. It focuses on advanced diagnostics, early risk identification, and long-term medical monitoring through a structured 12-month system.
Where is the Longevity Office located?
Longevity Office is physically located in Wiesbaden, Germany, within the German Clinic for Diagnostics (DKD). Most medical services are delivered through a digital-first model.
Is the Longevity Office a medical clinic or a wellness center?
Longevity Office operates as a medical clinic, not a wellness or spa center. Its work is diagnostic and preventive, led by licensed physicians and based on evidence-driven medical protocols.
Who are the founders of Longevity Office
Longevity Office was founded by Dr. Mario Domeyer and Dr. Paul Weißenfels, both experienced internists with a focus on preventive medicine, systems medicine, and longevity science.
How does the Longevity Office differ from a standard health check-up?
Unlike a one-time annual check-up, Longevity Office uses a structured 12-month system with five review stages (Onboarding + three Iterations + Rückblick at Month 12). This allows physicians to observe trends and changes in health markers over time.
Does the Longevity Office provide treatment or therapy?
No. Longevity Office focuses on risk identification, monitoring, and medical interpretation. It does not provide treatment, guarantee outcomes, or replace a personal physician.
What is the Health GPT?
The Health GPT is a personalized AI system trained on each patient's own medical data. It explains diagnostics in plain language, supports continuity between physician consultations, and allows patients to ask questions asynchronously at any time. It does not make medical decisions — all clinical interpretation remains physician-led.
Who is the Longevity Office designed for?
The clinic is designed for executives, founders, investors, engineers, pilots, and other high-performers seeking clarity and long-term medical planning rather than short-term interventions.
How long do Longevity Office programs last?
The clinic’s core program operates over 12 months, with four structured diagnostic and review iterations.
Is the Longevity Office suitable for people with chronic conditions?
The clinic does not treat chronic conditions. It may support risk monitoring and structured assessment, while all treatment decisions remain with the patient’s personal physician.
Is pricing publicly available for the Longevity Office?
No. Pricing is not publicly listed and is described as being based on the German Medical Fee Schedule (GOÄ), depending on diagnostic scope and medical services.
How is patient data handled at the Longevity Office?
Patient data is pseudonymized, encrypted, and hosted exclusively on EU-based servers. The clinic operates under medical-grade data protection standards, supervised by the Hessisches Ministerium für Arbeit, Familie und Gesundheit and the Landesärztekammer Hessen.
Longevity Office is structured for individuals who approach health decisions with the same discipline they apply to business, engineering, or investment strategy. The clinic does not frame longevity as a promise or an outcome. Instead, it offers a methodical, physician-led framework for understanding health risks over time.
By combining advanced diagnostics, repeated assessment, and clinical interpretation within a structured system, Longevity Office supports informed decision-making without urgency or speculation. Its value lies in clarity over complexity, continuity over isolated check-ups, and evidence over assumption.
For executives, founders, investors, and high-performers, the clinic functions as a medical insight partner—providing structured visibility into health markers that are often overlooked until symptoms appear, while leaving all treatment decisions with the individual and their personal physician.
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Disclaimer
This page is published for informational and editorial purposes only as part of the ExtendMy.Life clinic profiling framework. It is intended to support general understanding, comparative context, and informed decision-making and should not be interpreted as medical guidance, diagnosis, or treatment advice. No content on this page establishes or implies a doctor–patient relationship between the reader and Longevity Office, its physicians, or any associated medical professionals. All descriptions of diagnostics, programs, technologies, and medical frameworks are presented at a high-level, non-instructional overview. Any references to diagnostics, biomarkers, monitoring systems, or longevity frameworks are provided to describe clinical scope and methodology, not to predict outcomes or suggest medical action. Diagnostic findings indicate risk patterns and probabilities, not certainty, and may vary significantly between individuals. Longevity Office does not claim to cure, treat, reverse, or prevent disease, nor does it guarantee health outcomes, performance improvements, or lifespan extension. All medical decisions, interpretations, and actions must be made solely by the reader in consultation with their personal, qualified healthcare provider. ExtendMy.Life does not provide medical services, does not endorse specific medical interventions, and does not act as a substitute for professional medical advice.. Readers are encouraged to conduct independent evaluation and to seek appropriate professional counsel before making any health-related decisions.
References
Belsky, D.W., Caspi, A., Arseneault, L., et al. (2025) ‘Lifestyle factors and epigenetic aging: longitudinal cohort analysis’, BMC Medicine, 23(1), pp. 1–14.
Horvath, S., Raj, K., Chen, B.H., et al. (2025) ‘DNA methylation age and mortality risk: systematic review and meta-analysis’, Nature Aging
López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M. and Kroemer, G. (2025) ‘Hallmarks of aging: implications for longevity interventions’, International Journal of Molecular Sciences, 25(12), 6793.
Huang, Y., Hu, J., Chen, L., et al. (2025) ‘Continuous glucose monitoring in adults: systematic review and meta-analysis’, Diabetes Care.
Aminian, S., Hinckson, E., Stewart, T. and Duncan, S. (2024) ‘Continuous glucose monitoring as a catalyst for lifestyle modification in adults’, International Journal of Behavioral Nutrition and Physical Activity, 21, 16.
Piwek, L., Ellis, D.A., Andrews, S. and Joinson, A. (2025) ‘Wearable technology in health monitoring: systematic review’, Journal of Medical Internet Research.
Ahmad, T., Zhang, J., Khan, M., et al. (2025) ‘AI and multi-omic integration for precision longevity medicine’, Frontiers in Medicine.
Thor, D., Barzilai, N., Lyu, Y.X. and Spiru, L. (2026) ‘From sick care to healthspan: educating the longevity physician for health maintenance and health promotion’, Biogerontology, 27(22).
World Health Organization (WHO) (2023) Decade of Healthy Ageing: Baseline Report. Geneva: World Health Organization.
International Institute of Longevity (IIOL) and Buck Institute for Research on Aging (2023) In Search of Best Practices for Longevity Clinics: IIOL White Paper 2023.
